Mechanoregulation in Hematopoiesis and Hematologic Disorders

The human microbiome in hematopoiesis and hematologic disorders.

Humans are now understood to be in complex symbiosis with a diverse ecosystem of microbial organisms, including bacteria, viruses, and fungi. Efforts to characterize the role of these microorganisms, commonly referred as the microbiota, in human health have sought to answer the fundamental questions of what organisms are present, how are they functioning to interact with human cells, and by wha...

Abnormal ("ringed") sideroblasts in various hematologic and non-hematologic disorders.

The Notch signaling pathway in hematopoiesis and hematologic malignancies.

Iron Metabolism & Its Disorders Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo Igor Theurl, Andrea Schroll, Manfred Nairz, Markus Seifert, Milan Theurl, Thomas Sonnweber, Hasan Kulaksiz, and Guenter Weiss Leukemogenesis MLL-ENL leukemia burden initiated in femoral diaphysis and preceded by mature B-cell depletion Agnieszka Jara...

Parvovirus-B19 and hematologic disorders.

Parvovirus-B19 (PV-B19) is a member of Parvoviridae, which is one of the smallest DNA viruses. PV-B19-associated diseases usually serve as a good representation of the balance of virus, host response and the immune system. The diseases manifested with PV-B19 are erythema infectiosum, which is common in children, hydrops fetalis, transient pure red cell aplasia in patients with chronic hemolytic...

Chapter 7: Hematologic Disorders and Kidney Disease

Pathogenesis Multiple myeloma (MM) is a hematologic malignancy involving the pathologic proliferation of terminally differentiated plasma cells. It is the second most common hematologic malignancy behind non-Hodgkin lymphoma, with an annual incidence of 4–7 cases per 100,000 in the United States. Clinical symptoms are due to osteolysis of the bone, suppression of normal hematopoiesis, and the o...